Imaging biomarkers have helped to advance drug development and one of the areas that has seen the greatest impact from imaging biomarkers has been in the advancement of therapeutics for rheumatoid arthritis (RA). This presentation reviews the use of imaging biomarkers and then highlights their use in RA drug studies. These slides were presented as a virtual meeting of the International Society of Magnetic Resonance in Medicine (ISMRM) MR in Drug Research Study Group in April 2018. Video of the presentation is available to ISMRM members at: ISMRM Video Presentation
Rejecting the hypothesis—The Engineering Method as an Alternative to the Scientific Method.
Ever heard of the Engineering Method? No? Neither have most engineers. The Scientific Method, built around the development and testing of a hypothesis, has been and continues to be fundamental to advancing our knowledge of the world around us. However, sometimes the hypothesis neither helps guide the methodology nor helps to answer the study questions. In these cases, the Engineering Method, which doesn’t rely on a hypothesis, can offer a better alternative to the Scientific Method. This article will use examples from a school science fair to demonstrate the shortcomings of the hypothesis based Scientific Method and how the Engineering Method can be effectively applied to answer those same questions. Though the Engineering Method is almost unheard of, it is not a new idea. However, it is time that we introduce the Engineering Method into the classroom and begin an open discussion of when the Scientific Method is appropriate and when it isn’t.
Achieving Success Through Active Vendor Management
The concept is great! Leverage the technology of small creative groups to advance your company’s goals. What could possibly go wrong? Unfortunately, misaligned expectations and lack of experience in delivering often lead to project failure. However, with a little up front planning and active vendor management these problems can be eliminated helping to ensure success. This white paper describes how to achieve success through active vendor management.